The effect of free fatty acids (FFA) on first-pass hepatic insulin extraction in vivo by Stephaine Renee Wiesenthal

Cover of: The effect of free fatty acids (FFA) on first-pass hepatic insulin extraction in vivo | Stephaine Renee Wiesenthal

Published by National Library of Canada in Ottawa .

Written in English

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Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1998.

Book details

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19221240M
ISBN 100612340945

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Edwin N. Frankel, in Lipid Oxidation (Second Edition), 1 Hydrolytic rancidity. The hydrolysis of polyunsaturated lipids in cereals produces free fatty acids that undergo further enzymatic or non-enzymatic oxidation to form volatile and non-volatile undesirable flavor compounds.

Lipoxygenases act mainly on free fatty acids, which are also more easily oxidized than those esterified as. Objective: Free fatty acids (FFAs) exert a stimulatory effect on the hypothalamic-pituitary-adrenal (HPA) axis in animals and inhibit spontaneous ACTH and cortisol secretion in humans.

Patients with anorexia nervosa display concomitant HPA axis hyperactivity and increased lipolysis. We studied the effects of a lipid load on ACTH and cortisol secretion in patients with anorexia nervosa in. Studies were performed in nine male patients with moderate hypertension.

Treatment with metoprolol, mg The effect of free fatty acids book times daily for weeks, had no effect on the plasma level of glycerol, free fatty acids, triglycerides or glucose under basal conditions, neither in the supine nor in the upright position.

“Cancer cannot exist in the human body unless there are unsaturated fats in the diet.” – Dr. Ray Peat. Unsaturated fats are one of the most toxic and damaging components of a modern diet, and the list of harmful effects from the consumption of polyunsaturated fats (PUFA) is vast.

The free fatty acids content of the samples influence biodiesel yield and purity. • The contents of minor components as monoglycerides reduce the quality of biodiesel. • Biodiesel sample with high purity was obtained using an experimental design by:   Omega-3 and omega-6 fatty acids constitute 30–35% of total brain fatty acids and have beneficial effects on cognitive function.

During brain development, especially in the embryonic stage, polyunsaturated fatty acids are critical for cell proliferation and neuronal differentiation, and their deprivation results in by: Free fatty acids (FFA) are produced by the hydrolysis of oils and fats.

The level of FFA depends on time, temperature and moisture content because the oils and fats are exposed to various environments such as storage, processing, heating or frying. Since FFA are less stable than neutral oil, they are more pr. Recent evidence has demonstrated that stimulation of FFAR2 with the SCFA acetate and propionate causes a reduction in free fatty acid release from the adipocyte, and this effect is lost in tissue from the Ffar2 knockout mouse.

7 Using 3T3-L1 cells, it has been suggested that exposure of adipocytes to low concentrations of acetate and propionate. Storage with oxygen absorber accelerated free fatty acids accumulation in the lipids. • Oxygen absorber would prevent oxidative degradation of free fatty acids. • Antioxidative effect of oxygen absorber was confirmed by tocochromanols content.

Vegetable fat consists of primarily non-volatile fat-soluble fatty acids. The main fatty acids in milk are C and C comprising between ~22–35 and 20–30% of total lipids, respectively. Fatty acids are present either in their free state, as free fatty acids (FFA) or esterified as bound fatty acids (FA) on the glycerides.

Objective: To investigate the effects of Tangzhiping Granule (TZPG) on blood lipids and free fatty acids (FFA) in rats with insulin resistant diabetes (IRD). Methods: A blank control group consisted of randomly selected normal rats was set up.

The remaining rats were established to IRD model by high-fat high-sugar diet feeding and streptozotocin injection. Almond is one of the most commonly consumed nuts worldwide, with health benefits associated with availability of bioactive compounds and fatty acids.

Almond is often eaten raw or after some processing steps. However, the latter can positively or negatively influence chemical and sensorial attributes of almonds. This work was carried out to assess the effects of two processing treatments.

program-specific Assistant Professor. His research interests include the effects of nutrients, including omega-3 fatty acids, and incretin hormones on the cardiovascular system. He has co-authored several peerreviewed publications in - these areas.

The fat content of the cookies were extracted and evaluated for iodine value, free fatty acids, saponification value and fatty acid composition. The fatty acid composition was analysed by. Tamar Smith, John E. Gerich, in Encyclopedia of Hormones, II.C Free Fatty Acids and Ketone Bodies.

Free fatty acids (FFA) and ketone bodies (β-hydroxybutyrate and acetoacetate), the predominant fuels in human, inhibit glucagon secretion in vivo and in has been suggested that pancreatic alpha-cell function may in fact be more sensitive to changes in FFA than to glucose.

Omega-3 fatty acids can have a broad range of effects on inflammation, oxidation, stability of phospholipid membranes, and the composition and volume of atherosclerotic plaque. 3 These effects may differ between EPA and docosahexaenoic acid (DHA), another omega-3 fatty acid.

Free fatty acids and blood ketone bodies were measured before and 1, 2, and 3 h after each MTT, and the next morning (overnight fast). RESULTS: Empagliflozin significantly reduced plasma glucose and insulin and reduced body weight vs. placebo.

Empagliflozin increased free fatty acids and total ketones bodies at day 1 and day BACKGROUND Phytosterols are partly removed during oil refining, and the magnitude of phytosterols loss largely depends on the refining conditions applied and the molecular conformation.

The aim of t. Scope: We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. This study was to investigate whether curcuminoids have beneficial effects on type 2 diabetic patients, and its possible mechanisms.

Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism.

In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption. Fatty acids are straight chain hydrocarbons possessing a carboxyl group (–COOH) group at one end, and a methyl group (–CH 3) at the other carbon next to the carboxylate is known as α, the next carbon β, and so forth.

Since biological fatty acids can be of different lengths, the last position is labelled as a "ω", the last letter in the Greek alphabet.

Omega-6 fatty acids are types of types are found in vegetable oils, including corn, evening primrose seed, safflower, and soybean types of omega-6 fatty acids are found in black currant seed, borage seed, and evening primrose oils.

Omega-6 fatty acids are used for many conditions, but so far, the best information that science can provide is that putting arachidonic acid, a. Fluorescent gold nanoclusters (AuNCs) are envisaged as a novel type of fluorophores.

This work reports on the first comparative study investigating the effect of presence/absence/abundance of fatty acids (namely palmitic acid, PA) or other substances (like glycoproteins and globulins) in the protein (bovine serum albumin, BSA) on synthesis and properties of the final AuNCs.

Goat meat is considered healthy because it has fewer calories and fat than meat from other traditional meat species. It is also rich in branched chain fatty acids that have health advantages when consumed. We studied the effects of maternal milk and milk replacers fed to suckling kids of four breeds on the straight and branched fatty acid compositions of their muscle.

In addition, the proximal. A rapid and simple method for the determination of esterified fatty acids and for total fatty acids in blood.

J Clin Pathol. May; 6 (2)– [PMC free article] Stumpf PK, Barber GA. Fat Metabolism in Higher Plants. VII. beta-Oxidation of Fatty Acids by Peanut Mitochondria. Plant Physiol. Jul; 31 (4)– [PMC free article]. Insulin resistance is a key metabolic defect in type 2 diabetes mellitus (T2DM) and precedes the onset of overt hyperglycemia by decades (1,2).Studies in humans and rodents consistently have demonstrated that experimental elevation in free fatty acids (FFA) in healthy subjects reduces insulin-stimulated glucose uptake in a dose-dependent manner ().

the fatty acid profile, and MIU and extra caloric effects when calculating the metabolizable energy and evaluating the overall metabolic and financials impact of adding fat to the diet.

In contrast to oils sourced from restaurants, the high free fatty acid levels found in acidulated oils are not an indication of lipid oxidation, producing. Background: Artemisia capillaris (AC) has been recognized as one of the promising candidates for hepatoprotective, hypoglycemic, hypolipidemic, antiobesitic and anti-inflammatory therapeutic effectiveness.

This study evaluated the inherent mechanism and anti-apoptotic activity of 30% ethanol extract of AC (AC extract) μg/ml on free fatty acids (FFAs)-induced HepG2 cellular steatosis and. The purpose of this study is to determine if changes in fasting glucose and fasting free fatty acids (FFA) concentrations alter postprandial glucose metabolism in non-diabetic and pre-diabetic humans.

Participation eligibility. Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Shogo Tokuyama, Kazuo Nakamoto, in Omega-3 Fatty Acids in Brain and Neurological Health, Toll Like Receptor 4. Saturated fatty acids activate toll like receptor 4 (TLR4) (Lee et al.,Huang et al., ).They also serve as an agonist for a complex of TLR4 and the lipid-binding accessory protein MD-2, or TLR4/MD2 complex, and they induce the production of inflammatory cytokines and.

There are the inherent limitations with the convention of grouping fatty acids based only on the number of double bonds, i.e. saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) insofar as describing the effects of fatty acids on human health and in developing dietary recommendations.

The "uncombined fatty acids" or "free fatty acids" found in the circulation of animals come from the breakdown (or lipolysis) of stored triglycerides. Because they are insoluble in water, these fatty acids are transported bound to plasma albumin.

The levels of "free fatty acids" in the blood are limited by the availability of albumin binding sites. In terms of effects on lowering blood pressure of omega-3 fatty acids, our findings are consistent with the previous meta-analysis of the effects of omega-3 acids on cardiometabolic biomarkers in type 2 diabetes by Lauren et al.

in which included patients. With respect to HbA1C, the effect of omega-3 fatty acids on HbA1C is controversial. Metabolism of fatty acids. Free fatty acids (FFA) are taken up into cells mainly by protein carriers in the plasma membrane and transported intracellularly via fatty acid-binding proteins (FABP).

The research led him to the discovery that free fatty acids play a vital role in glucose metabolism, a finding that launched major advances in understanding how the human body stores and uses energy. Dole found that a fatty meal had no effect on the level of free fatty acids in the plasma of his patients.

COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

Curcuminoids exert glucose‐lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double‐blind, placebo‐controlled trial Li‐Xin Na Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, P.

China. Since the publication of the bestselling second edition, mounting research into fatty acids reveals new and more defined links between the consumption of dietary fats and their biological health effects.

Whether consuming omega-3 to prevent heart disease or avoiding trans fats to preserve heart health, it is more and more clear that not only the qu5/5(3). Given the contrasting effects of the omega-3 and omega-6 fatty acids, a proper dietary balance between the two must be achieved to ensure optimal health benefits.

Essential fatty acids play an important role in the life and death of cardiac cells, immune system function, and blood pressure regulation. Effects of Age/Weight and Castration on Fatty Acids Composition in Pork Fat and the Qualities of Pork and Pork Fat in Meishan X Large White Pigs (Report) African Journal of Food, Agriculture, Nutrition and DevelopmentNov, 9, 8.

The Fats of Life delineates the importance of essential fatty acids, with a focus on distinctions between omega-3 and omega-6 fatty acid variants.

The chemical and biochemical characteristics of these fatty acids and their metabolism to a vast array of potent bioactive messengers are described in the context of their potential effects on Reviews: 2.

Fatty acid regulation is an essential process for all animals. A number of studies have shown that diet affects the levels/availability of fatty acids in the body but increasingly an evidence shows that disease states can alter the amounts within the body too. Fatty acid levels and availability have been altered by a number of diseases, disorders and reactions including inflammatory responses.This is the first comprehensive volume to look at the importance of short-chain fatty acids in digestion, the function of the large intestine and their role in human health.

Short-chain fatty acids are the major product of bacterial fermentation of dietary carbohydrates in the human and animal large intestine. They represent the major end products of digestive processes occurring in the caecum.

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